Pediatr Dev Pathol. 2003 Nov-Dec;6(6):552-7.

Concurrent infantile hemangioendothelioma and mesenchymal hamartoma in a developmentally arrested liver of an infant requiring hepatic transplantation.

Bejarano PA, Serrano MF, Casillas J, Dehner LP, Kato T, Mitral N, Rodriguez MM, Tzakis A.

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Department of Pathology, University of Miami School of Medicine, Jackson Memorial Hospital, 1611 NW 12th Avenue, Holtz Center-Room 2042, Miami, FL 33136, USA. pbejaran@med.miami.edu

Abstract

A newborn female underwent a surgical resection for a hepatic mass discovered prenatally by ultrasonography, and diagnosed pathologically as a mesenchymal hamartoma. Within 4 months after surgery, multiple cutaneous hemangiomas developed and a multinodular mass was detected in the liver. A liver biopsy showed an infantile hemangioendothelioma with type I features. An orthotopic liver transplant was performed due to the extensive nature of the hepatic involvement and progressive respiratory compromise. Virtually the entire liver was involved by a large infantile hemangioendothelioma. A multicystic mesenchymal hamartoma was also found on the left side. In addition, the uninvolved hepatic parenchyma had features recapitulating the fetal liver. This simultaneous involvement of the liver by a mesenchymal hamartoma and infantile hemangioendothelioma is unique. A review of the literature revealed only one incompletely characterized case with similar findings.

PMID:: 15018455; [PubMed - indexed for MEDLINE]

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