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J Urol. 2004 Apr;171(4):1402-7.

Alpha-linolenic acid and the risk of prostate cancer. What is the evidence?

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  • 1Department of Food Science, RMIT University, Melbourne, Victoria, Australia.

Abstract

PURPOSE:

Several studies have examined the association between polyunsaturated fatty acids and prostate cancer risk. We evaluated the evidence on the association between the essential polyunsaturated fatty acid, known as alpha-linolenic acid, and the risk of prostate cancer in humans.

MATERIALS AND METHODS:

We comprehensively reviewed published studies on the association between alpha-linolenic acid and the risk of prostate cancer using MEDLINE.

RESULTS:

A number of studies have shown a positive association between dietary, plasma or red blood cell levels of alpha-linolenic acid and prostate cancer. Other studies have demonstrated either no association or a negative association. The limitations of these studies include the assumption that dietary or plasma alpha-linolenic acid levels are positively associated with prostate tissue alpha-linolenic acid levels, and measurement errors of dietary, plasma and red blood cell alpha-linolenic acid levels.

CONCLUSIONS:

More research is needed in this area before it can be concluded that there is an association between alpha-linolenic acid and prostate cancer.

PMID:
15017185
[PubMed - indexed for MEDLINE]
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