Virology. 2004 Jan 20;318(2):463-73.

Viral DNA polymerase scanning and the gymnastics of Sendai virus RNA synthesis.

Kolakofsky D, Le Mercier P, Iseni F, Garcin D.

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Department of Genetics and Microbiology, University of Geneva School of Medicine, Switzerland. Daniel.Kolakofsky@medecine.unige.ch

Abstract

mRNA synthesis from nonsegmented negative-strand RNA virus (NNV) genomes is unique in tht the genome RNA is embedded in an N protein assembly (the nucleocapsid) and the viral RNA polymerase does not dissociate from the template after release of each mRNA, but rather scans the genome RNA for the next gene-start site. A revised model for NNV RNA synthesis is presented, in which RNA polymerase scanning plays a prominent role. Polymerase scanning of the template is known to occur as the viral transcriptase negotiates gene junctions without falling off the template.

PMID:: 15015496; [PubMed - indexed for MEDLINE]

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