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Biol Psychiatry. 2004 Mar 15;55(6):656-8.

Cavum septum pellucidum in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder.

Author information

  • 1Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Abstract

BACKGROUND:

Abnormally large cavum septum pellucidum has been reported in posttraumatic stress disorder; however, the origin of this association is uncertain.

METHODS:

We utilized magnetic resonance imaging to measure cavum septum pellucidum in pairs of identical twins discordant for combat exposure in Vietnam.

RESULTS:

Presence of abnormal cavum septum pellucidum was significantly correlated between exposed and unexposed twins, indicating that it is partially determined by heredity and/or shared environment. There was a greater proportion of cavum septum pellucidum in combat-exposed twins with posttraumatic stress disorder and their noncombat-exposed co-twins.

CONCLUSIONS:

The presence of abnormally large cavum septum pellucidum is a familial vulnerability factor for posttraumatic stress disorder.

PMID:
15013837
[PubMed - indexed for MEDLINE]
PMCID:
PMC2794416
Free PMC Article
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