Neuroimage. 2004 Mar;21(3):840-7.

Decreased cerebral activation during CPT performance: structural and functional deficits in schizophrenic patients.

Salgado-Pineda P, Junqué C, Vendrell P, Baeza I, Bargalló N, Falcón C, Bernardo M.

Source

Department of Psychiatry and Clínical Psychobiology, University of Barcelona, Institut d'investigacions Biomèdiques August Pi i Sunyer, Casanova 143, 08036 Barcelona, Spain.

Abstract

Voxel-based morphometry (VBM) allows the output of structural data in a Statistical Parametric Map of the brain in the same way that the SPM can do with functional data. Using functional magnetic resonance (fMR), we studied brain activation in 14 patients with schizophrenia and 14 matched normal controls. We found significant hypoactivation in patients in several regions, especially in the right hemisphere, in the dorsolateral frontal and temporal regions and in the inferior parietal. Subcortically, we found strong hypoactivity in the thalamus. The optimized VBM method revealed gray matter (GM) abnormalities in the bilateral supramarginal gyrus and cingulate cortex, and in the right inferior temporal regions. Three regions involved in attentional processes showed both structural and functional deficits: the thalamus, the anterior cingulate and the inferior parietal. The results suggest that these regions may be involved in the attentional deficit in schizophrenia.

PMID:: 15006650; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Sustained attention impairment correlates to gray matter decreases in first episode neuroleptic-naive schizophrenic patients. [Neuroimage. 2003]
Sustained attention impairment correlates to gray matter decreases in first episode neuroleptic-naive schizophrenic patients.
Salgado-Pineda P, Baeza I, Pérez-Gómez M, Vendrell P, Junqué C, Bargalló N, Bernardo M. Neuroimage. 2003 Jun; 19(2 Pt 1):365-75.
Association of cerebral deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized voxel-based morphometry and resting state functional connectivity study. [Am J Psychiatry. 2009]
Association of cerebral deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized voxel-based morphometry and resting state functional connectivity study.
Lui S, Deng W, Huang X, Jiang L, Ma X, Chen H, Zhang T, Li X, Li D, Zou L, et al. Am J Psychiatry. 2009 Feb; 166(2):196-205. Epub 2008 Nov 3.
Volumetric abnormalities associated with cognitive deficits in patients with schizophrenia. [Eur Psychiatry. 2008]
Volumetric abnormalities associated with cognitive deficits in patients with schizophrenia.
Wolf RC, Höse A, Frasch K, Walter H, Vasic N. Eur Psychiatry. 2008 Dec; 23(8):541-8. Epub 2008 Apr 22.
Review Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. [Am J Psychiatry. 2005]
Review Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies.
Honea R, Crow TJ, Passingham D, Mackay CE. Am J Psychiatry. 2005 Dec; 162(12):2233-45.
Review Recent advances in the neuropathology of schizophrenia. [Schizophr Bull. 1993]
Review Recent advances in the neuropathology of schizophrenia.
Bogerts B. Schizophr Bull. 1993; 19(2):431-45.

See reviews... See all...

Cited by 11 PubMed Central articles

Are Bipolar Disorder and Schizophrenia Neuroanatomically Distinct? An Anatomical Likelihood Meta-analysis. [Front Hum Neurosci. 2010]
Are Bipolar Disorder and Schizophrenia Neuroanatomically Distinct? An Anatomical Likelihood Meta-analysis.
Yu K, Cheung C, Leung M, Li Q, Chua S, McAlonan G. Front Hum Neurosci. 2010 Oct 26; 4:189. Epub 2010 Oct 26.
Assessments of function and biochemistry of the anterior cingulate cortex in schizophrenia. [Biol Psychiatry. 2010]
Assessments of function and biochemistry of the anterior cingulate cortex in schizophrenia.
Reid MA, Stoeckel LE, White DM, Avsar KB, Bolding MS, Akella NS, Knowlton RC, den Hollander JA, Lahti AC. Biol Psychiatry. 2010 Oct 1; 68(7):625-33. Epub 2010 Jun 8.
Review Executive function, neural circuitry, and genetic mechanisms in schizophrenia. [Neuropsychopharmacology. 2010]
Review Executive function, neural circuitry, and genetic mechanisms in schizophrenia.
Eisenberg DP, Berman KF. Neuropsychopharmacology. 2010 Jan; 35(1):258-77.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Decreased cerebral activation during CPT performance: structural and functional ...
Decreased cerebral activation during CPT performance: structural and functional deficits in schizophrenic patients.
Neuroimage. 2004 Mar ;21(3):840-7.

PubMed
Lipid peroxidation and active calcium transport in inside-out vesicles of red bl...
Lipid peroxidation and active calcium transport in inside-out vesicles of red blood cells from preeclamptic women.
Int J Biochem Cell Biol. 2004 May ;36(5):806-13.

PubMed
A novel ex vivo angiogenesis assay based on electroporation-mediated delivery of...
A novel ex vivo angiogenesis assay based on electroporation-mediated delivery of naked plasmid DNA to skeletal muscle.
Mol Ther. 2004 Mar ;9(3):464-74.

PubMed
Collagenous enterocolitis: a manifestation of gluten-sensitive enteropathy.
Collagenous enterocolitis: a manifestation of gluten-sensitive enteropathy.
J Clin Gastroenterol. 1992 Jul ;15(1):45-51.

PubMed
Long-term clinical and molecular follow-up of large animals receiving retroviral...
Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia.
Mol Ther. 2004 Mar ;9(3):389-95.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: