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J Antibiot (Tokyo). 1992 Jun;45(6):886-91.

Adipostatins A and B, new inhibitors of glycerol-3-phosphate dehydrogenase.

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  • 1Research Institute of House Food Ind. Co., Ltd., Osaka, Japan.


As a result of screening for inhibitors of glycerol-3-phosphate dehydrogenase, which may be effective to prevent corpulence, we isolated two inhibitors named adipostatin A and adipostatin B from the culture broth of Streptomyces cyaneus 2299-SV1. Their structures have been established to be 5-n-pentadecylresorcinol and 5-isopentadecylresorcinol, respectively. Adipostatin A and adipostatin B inhibited glycerol-3-phosphate dehydrogenase at the IC50 values of 4.1 microM and 4.5 microM, respectively. These compounds prevented triglyceride accumulation in 3T3-L1 cells at a concentration of the microM level.

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