Trends Biochem Sci. 2004 Mar;29(3):143-51.

The C2 domains of synaptotagmin--partners in exocytosis.

Source

Department of Physiology, University of Wisconsin, 1300 University Avenue, SMI 129, Madison, WI 53706, USA.

Abstract

Rapid signaling between neurons relies on the Ca(2+)-triggered exocytosis of neurotransmitters. Release is mediated by 'kiss-and-run' or complete fusion of secretory organelles with the plasma membrane. Current models indicate that exocytosis is regulated by synaptotagmin I (syt) and mediated by SNARE (soluble NSF-attachment protein receptor) proteins. Syt senses Ca(2+) via two conserved motifs, C2A and C2B. C2B engages a wider array of effector molecules than C2A and appears to play a more crucial role in synaptic transmission. However, it has recently become clear that the tandem C2 domains of syt influence each another in unexpected ways. Here, we focus on recent structure-function studies that are beginning to provide insights into the mechanism through which the C2 domains of syt trigger exocytosis.

PMID:: 15003272; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Molecular Biology Databases

CALCIUM, ELEMENTAL - HSDB

Supplemental Content

Save items

Related citations in PubMed

The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis. [J Cell Biol. 2001]
The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis.
Earles CA, Bai J, Wang P, Chapman ER. J Cell Biol. 2001 Sep 17; 154(6):1117-23. Epub 2001 Sep 10.
Mutations in the effector binding loops in the C2A and C2B domains of synaptotagmin I disrupt exocytosis in a nonadditive manner. [J Biol Chem. 2003]
Mutations in the effector binding loops in the C2A and C2B domains of synaptotagmin I disrupt exocytosis in a nonadditive manner.
Wang P, Wang CT, Bai J, Jackson MB, Chapman ER. J Biol Chem. 2003 Nov 21; 278(47):47030-7. Epub 2003 Sep 8.
Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions. [Neuron. 2004]
Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.
Bai J, Wang CT, Richards DA, Jackson MB, Chapman ER. Neuron. 2004 Mar 25; 41(6):929-42.
Review Role of synaptotagmin in Ca2+-triggered exocytosis. [Biochem J. 2002]
Review Role of synaptotagmin in Ca2+-triggered exocytosis.
Tucker WC, Chapman ER. Biochem J. 2002 Aug 15; 366(Pt 1):1-13.
Review Roles of SNARE proteins and synaptotagmin I in synaptic transmission: studies at the Drosophila neuromuscular synapse. [Neurosignals. 2003]
Review Roles of SNARE proteins and synaptotagmin I in synaptic transmission: studies at the Drosophila neuromuscular synapse.
Kidokoro Y. Neurosignals. 2003 Jan-Feb; 12(1):13-30.

See reviews... See all...

Cited by 40 PubMed Central articles

Identification of differentially expressed genes in SHSY5Y cells exposed to okadaic acid by suppression subtractive hybridization. [BMC Genomics. 2012]
Identification of differentially expressed genes in SHSY5Y cells exposed to okadaic acid by suppression subtractive hybridization.
Valdiglesias V, Fernández-Tajes J, Pásaro E, Méndez J, Laffon B. BMC Genomics. 2012 Jan 27; 13:46. Epub 2012 Jan 27.
Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation. [Am J Hum Genet. 2011]
Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation.
Doi H, Yoshida K, Yasuda T, Fukuda M, Fukuda Y, Morita H, Ikeda S, Kato R, Tsurusaki Y, Miyake N, et al. Am J Hum Genet. 2011 Aug 12; 89(2):320-7.
Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together. [Biochemistry. 2011]
Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together.
Kuo W, Herrick DZ, Cafiso DS. Biochemistry. 2011 Apr 5; 50(13):2633-41. Epub 2011 Mar 7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The C2 domains of synaptotagmin--partners in exocytosis.
The C2 domains of synaptotagmin--partners in exocytosis.
Trends Biochem Sci. 2004 Mar ;29(3):143-51.

PubMed
Prevention of aggregation after refolding by balanced stabilization-destabilizat...
Prevention of aggregation after refolding by balanced stabilization-destabilization: production of the Arabidopsis thaliana protein APG8a (At4g21980) for NMR structure determination.
Protein Expr Purif. 2004 Apr ;34(2):280-3.

PubMed
A randomized, controlled comparison of the efficacy and tolerability of low and ...
A randomized, controlled comparison of the efficacy and tolerability of low and high doses of haloperidol in the treatment of first-episode psychosis.
Int J Neuropsychopharmacol. 2004 Jun ;7(2):125-31. Epub 2004 Mar 5 .

PubMed
MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional ...
MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins.
Genome Biol. 2004 ;5(3):R21. Epub 2004 Feb 13 .

PubMed
The ABC transporter gene family of Caenorhabditis elegans has implications for t...
The ABC transporter gene family of Caenorhabditis elegans has implications for the evolutionary dynamics of multidrug resistance in eukaryotes.
Genome Biol. 2004 ;5(3):R15. Epub 2004 Feb 11 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The C2 domains of synaptotagmin--partners in exocytosis.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 40 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information