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Genome Biol. 2004;5(3):R21. Epub 2004 Feb 13.

MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins.

Author information

  • 1IMP Research Institute of Molecular Pathology, Dr, Bohr-Gasse 7, A-1030 Vienna, Austria. stroh@imp.univie.ac.at

Abstract

We evaluated the evolutionary conservation of glycine myristoylation within eukaryotic sequences. Our large-scale cross-genome analyses, available as MYRbase, show that the functional spectrum of myristoylated proteins is currently largely underestimated. We give experimental evidence for in vitro myristoylation of selected predictions. Furthermore, we classify five membrane-attachment factors that occur most frequently in combination with, or even replacing, myristoyl anchors, as some protein family examples show.

PMID:
15003124
[PubMed - indexed for MEDLINE]
PMCID:
PMC395771
Free PMC Article

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