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Genome Biol. 2004;5(3):R18. Epub 2004 Mar 1.

Exploratory differential gene expression analysis in microarray experiments with no or limited replication.

Author information

  • 1Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Morgan Hall, Berkeley, CA 94720, USA. Avl53@aol.com

Abstract

We describe an exploratory, data-oriented approach for identifying candidates for differential gene expression in cDNA microarray experiments in terms of alpha-outliers and outlier regions, using simultaneous tolerance intervals relative to the line of equivalence (Cy5 = Cy3). We demonstrate the improved performance of our approach over existing single-slide methods using public datasets and simulation studies.

PMID:
15003121
[PubMed - indexed for MEDLINE]
PMCID:
PMC395768
Free PMC Article

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