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J Pediatr. 2004 Mar;144(3):397-9.

The development of hepatocellular carcinoma among prospectively followed children with chronic hepatitis B virus infection.

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  • 1Department of Pediatrics, National Taiwan University Hospital, and the Department of Pediatrics, Cardinal Tien Hospital, Taipei, Taiwan.


We prospectively followed 426 children with chronic hepatitis B virus infection. During 6250 person-years, 2 boys developed hepatocellular carcinoma, with an incidence of 32 per 100,000 person-years. Both had e antigen seroconversion in early childhood and cirrhosis. Early e antigen seroconversion and/or cirrhosis may be risk factors for hepatocellular carcinoma.

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