Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuromolecular Med. 2004;5(1):51-8.

Opioid receptor regulation.

Author information

  • 1Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, CA 94143-2140, USA. zastrow@itsa.ucsf.edu

Abstract

Opioid receptors are regulated by multiple mechanisms, which are believed to contribute to the physiological plasticity of the endogenous opioid system in response to natural neuropeptides, as well as clinically relevant opiate drugs. Considerable progress has been made in elucidating molecular and cellular mechanisms of opioid receptor regulation. The article summarizes this progress by focusing on cell biological studies using cultured heterologous cell models and primary cultures of central nervous system neurons. These studies have identified multiple subcellular locations at which specific aspects of opioid receptor signaling and membrane trafficking are regulated. They have also identified unexpected regulatory effects of opiate drugs that may be relevant to pharmacotherapy.

PMID:
15001812
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk