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    Science. 2004 Mar 5;303(5663):1512-4.

    Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.

    Nie Z, Schweitzer P, Roberts AJ, Madamba SG, Moore SD, Siggins GR.

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    Department of Neuropharmacology and Alcohol Research Center, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

    Abstract

    The central amygdala (CeA) plays a role in the relationship among stress, corticotropin-releasing factor (CRF), and alcohol abuse. In whole-cell recordings, both CRF and ethanol enhanced gamma-aminobutyric acid-mediated (GABAergic) neurotransmission in CeA neurons from wild-type and CRF2 receptor knockout mice, but not CRF1 receptor knockout mice. CRF1 (but not CRF2) receptor antagonists blocked both CRF and ethanol effects in wild-type mice. These data indicate that CRF1 receptors mediate ethanol enhancement of GABAergic synaptic transmission in the CeA, and they suggest a cellular mechanism underlying involvement of CRF in ethanol's behavioral and motivational effects.

    PMID:
    15001778
    [PubMed - indexed for MEDLINE]

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