Immun Infekt. 1992 Jul;20(3):91.

[Impaired induction of chemiluminescence and function of polymorphonuclear neutrophilic granulocytes in diabetes mellitus].

[Article in German]

Marhoffer W, Stein M, Schleinkofer L, Federlin K.

Source

Medizinische Klinik III und Poliklinik, Universität Giessen.

Abstract

The aim of this study was to investigate PMN-chemiluminescence response as a measure of respiratory burst activity and the phagocytic PMN function "ingestion" with regard to metabolic control parameters in diabetes mellitus (d.m.) in comparison to healthy controls. Our findings demonstrated a significant reduction of chemiluminescence response and ingestion in diabetic patients compared to controls (p less than 0.01 resp.); further an inverse relation of metabolic control parameters in d.m. and PMN impairment, suggesting inhibitory effects on PMN function, thus leading or contributing at least in part to altered host defense.

PMID:: 1500077; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Tetradecanoylphorbol Acetate

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Diabetes - MedlinePlus Health Information

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12-O-TETRADECANOYLPHORBOL-13-ACETATE - HSDB

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Related citations in PubMed

[Impaired function of polymorphonuclear neutrophilic granulocytes in rheumatoid arthritis]. [Immun Infekt. 1993]
[Impaired function of polymorphonuclear neutrophilic granulocytes in rheumatoid arthritis].
Marhoffer W, Stein M, Federlin K. Immun Infekt. 1993 Apr; 21 Suppl 1:15-6.
Impairment of polymorphonuclear leukocyte function and metabolic control of diabetes. [Diabetes Care. 1992]
Impairment of polymorphonuclear leukocyte function and metabolic control of diabetes.
Marhoffer W, Stein M, Maeser E, Federlin K. Diabetes Care. 1992 Feb; 15(2):256-60.
Monitoring of polymorphonuclear leukocyte functions in diabetes mellitus--a comparative study of conventional radiometric function tests and low-light imaging systems. [J Biolumin Chemilumin. 1994]
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Marhoffer W, Stein M, Schleinkofer L, Federlin K. J Biolumin Chemilumin. 1994 May-Jun; 9(3):165-70.
[Reduced phagocytic capacity of circulating granulocytes in diabetes mellitus]. [Immun Infekt. 1992]
[Reduced phagocytic capacity of circulating granulocytes in diabetes mellitus].
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Evidence of ex vivo and in vitro impaired neutrophil oxidative burst and phagocytic capacity in type 1 diabetes mellitus. [Diabetes Res Clin Pract. 1993]
Evidence of ex vivo and in vitro impaired neutrophil oxidative burst and phagocytic capacity in type 1 diabetes mellitus.
Marhoffer W, Stein M, Schleinkofer L, Federlin K. Diabetes Res Clin Pract. 1993 Mar; 19(3):183-8.

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