Breast Cancer Res Treat. 2004 Jan;83(1):87-9.

Pilot study using gabapentin for tamoxifen-induced hot flashes in women with breast cancer.

Pandya KJ, Thummala AR, Griggs JJ, Rosenblatt JD, Sahasrabudhe DM, Guttuso TJ, Morrow GR, Roscoe JA.

Source

James P. Wilmot Cancer Center, University of Rochester, Rochester, NY 14642 USA. kishan_pandya@urmc.rochester.edu

Abstract

In this pilot study, 22 women with breast cancer on tamoxifen therapy with at least two hot flashes a day took oral gabapentin at 300 mg three times a day for 4 weeks. The 16 women who completed the study had a mean decrease in hot flash duration of 73.6% (P = 0.027), frequency of 44.2% (P < 0.001), and severity of 52.6% (P < 0.001), with a complete response in 8/16 women. Side effects reported by four women who did not complete 4 weeks of the study were nausea (1/4), rash (1/4) and excessive sleepiness (3/4). Two additional patients did not provide complete data. Gabapentin is a promising new agent in the treatment of tamoxifen induced hot flashes, and should be studied further.

PMID:: 14997058; [PubMed - indexed for MEDLINE]

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