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1: Expert Opin Pharmacother. 2004 Feb;5(2):255-61.Click here to read Links

Combating opportunistic infections: coccidioidomycosis.

Ampel NM.

University of Arizona, Southern Arizona Veterans Affairs Medical Center, Tucson, AZ 85723, USA. nampel@u.arizona.edu

Coccidioidomycosis is a growing problem in the southwestern US. Although most cases of symptomatic coccidioidomycosis occur in healthy individuals, individuals with depressed cellular immunity are at particular risk. These include individuals with HIV infection, those who have undergone allogeneic transplantation and others on immunosuppressive medications. Most instances of primary pulmonary coccidioidomycosis do not require antifungal therapy. However, almost all cases of disseminated coccidioidomycosis will require such therapy. The triazole antifungals, fluconazole and itraconazole, are effective therapies for coccidioidomycosis. Amphotericin B is now reserved for severe or recalcitrant cases. Coccidioidal meningitis requires lifelong therapy with triazole antifungals. Intrathecal amphotericin B is required for those cases that fail. Prevention of coccidioidomycosis by environmental control is difficult. In the future, immunisation or immune modulation may offer protection.

PMID: 14996623 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Fluconazole (Diflucan® )

    Fluconazole is used to treat fungal infections, including yeast infections of the vagina, mouth, throat, esophagus (tube leading from the mouth to the stomach), abdomen (area between the chest and waist), lungs, blood, a...

  • Itraconazole (Sporanox® )

    Itraconazole capsules are used to treat fungal infections that begin in the lungsand can spread through the body. Itraconazole capsules are also used to treat fungal infections of the fingernails and/or toenails. Itracon...

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