Molecular genetics of human cognition. [Mol Interv. 2002]

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1: Mol Interv. 2002 Oct;2(6):376-91, 339. Links

Molecular genetics of human cognition.

Weeber EJ, Levenson JM, Sweatt JD.

Division of Neuroscience, Baylor College of Medicine 1 Baylor Plaza, Houston, TX 77030, USA.

Our understanding of the molecular underpinnings of human cognition has been greatly aided by the convergent synergy of clinical, genetic, and signaling research. By identifying the mutated genes that give rise to syndromes of mental retardation or cognitive defects in patients, and by placing the associated gene products within signaling networks, researchers are piecing together how learning occurs and how memories are formed and sustained.

PMID: 14993414 [PubMed - indexed for MEDLINE]

Dendritic anomalies in disorders associated with mental retardation. [Cereb Cortex. 2000]
Dendritic pathology in mental retardation: from molecular genetics to neurobiology. [Genes Brain Behav. 2006]
Learning, memory, and transcription factors. [Pediatr Res. 2003]
Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning. [Hum Mol Genet. 2002]
Syndromes of disordered chromatin remodeling. [Clin Genet. 2003]
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Molecular genetics of human cognition.

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