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Mol Interv. 2002 Oct;2(6):363-75, 339.

Apolipoprotein E, amyloid, and Alzheimer disease.

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  • 1Neuroscience Discovery Research, Lilly Research Laboratories Indianapolis, IN 46285, USA.


Despite important inroads into the molecular pathology of Alzheimer disease, effective long-term treatment for the condition remains elusive. Among the many gene products that are recognized as factors in the disease is apolipoprotein ( (apoE). The risk that specific isoforms of apoE pose with regard to Alzheimer Disease clearly varies, and so the roles that apoE plays in the brain will be crucial to a full understanding of the disease and to efforts to develop effective therapies.

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