Send to:

Choose Destination
See comment in PubMed Commons below
Mol Interv. 2002 Oct;2(6):352-5,338.

Phospholipase C-gamma1: a phospholipase and guanine nucleotide exchange factor.

Author information

  • 1Department of Cell Biology and Signal Transduction Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.


Although phospholipase C-gamma (PLC-gamma) participates in cellular mitogenesis, evidence indicates that the catalytic activity of PLC-gamma (to hydrolyze certain phosphoinositides) is nonessential to the process. So how is it that PLC-gamma is necessary but its lipase activity is not? Recently published results from Snyder and colleagues describe the ability of PLC-gamma to facilitate guanine nucleotide exchange for the recently identified nucleus-localized GTPase PIKE, which acts to enhance the enzymatic activity of phosphatidylinositol 3'-kinase (PI3K). The authors contend that the SH3 domain, rather than the catalytic domain, of PLC-gamma is required for aiding PIKE, and furthermore, that the mitogenic activity of PLC-gamma depends not on its phospholipase activity, but rather on its interaction with PIKE. Wang and Moran examine the results and piece together a picture of how PLC-gamma cooperates with PIKE.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk