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Nat Med. 2004 Apr;10(4):363-4. Epub 2004 Feb 29.

Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease.

Author information

  • 1Division of Nephrology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. torres.vicente@mayo.edu

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end-stage renal disease. The vasopressin V2 receptor (VPV2R) antagonist OPC31260 has been effective in two animal models of PKD with pathologies that are probably related. Here we show, in a mouse model of ADPKD (Pkd2(-/tm1Som)), a similar cellular phenotype and response to OPC31260 treatment, with reduction of renal cyclic AMP (cAMP) levels, prevention of renal enlargement, marked inhibition of cystogenesis and protection of renal function.

PMID:
14991049
[PubMed - indexed for MEDLINE]
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