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[Major role of stromal cell derived factor and its receptor CXCR4 in the mobilization and homing of hematopoietic stem/progenitor cells - review].

[Article in Chinese]

Author information

  • 1The State Key Laboratory of Biomembrane and Membrane biotechnology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.

Abstract

Stromal cell derived factor (SDF), expressing on bone marrow stromal cells is a CXC-type chemokine, which specifically chemoattracts hematopoietic stem cells (HSCs) expressing CXCR4. SDF plays important roles in homing and mobilizing of HSCs. In this paper the regulatory mechanism of SDF/CXCR4 in the HSC migration process is mainly reviewed.

PMID:
14989785
[PubMed - indexed for MEDLINE]
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