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Curr Biol. 2004 Feb 3;14(3):R129-38.

Regulation of notch signaling activity.

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  • 1CNRS UMR 8542, Ecole Normale SupĂ©rieure, Paris, France. schweisg@wotan.ens.fr

Abstract

Cell-cell signalling mediated by the receptor Notch is used widely across the metazoans to determine cell fate and regulate pattern formation. Notch signals via a conserved regulated intramembrane proteolysis. Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time.

PMID:
14986688
[PubMed - indexed for MEDLINE]
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