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J Cell Biol. 2004 Mar 1;164(5):641-5. Epub 2004 Feb 23.

The peroxisome: orchestrating important developmental decisions from inside the cell.

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  • 1Department of Biology, Concordia University, 7141 Sherbrooke St., West SP Building, Room SP-501-9, Montreal, Quebec H4B 1R6, Canada.

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  • J Cell Biol. 2004 Apr 12;165(1):following 154.


The peroxisome has long been known for its role in lipid metabolism and hydrogen peroxide detoxification. However, growing evidence supports the view that this organelle can also function both as an intracellular signaling compartment and as an organizing platform that orchestrates certain developmental decisions from inside the cell. This review highlights various strategies that peroxisomes employ to regulate the processes of development, differentiation, and morphogenesis and critically evaluates several molecular mechanisms by which peroxisomes promote these processes.

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