Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell. 2004 Feb 20;116(4):491-7.

Tumor necrosis factor: an apoptosis JuNKie?

Author information

  • 1Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Abstract

TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFkappaB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF.

PMID:
14980217
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk