Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Cell Biochem. 2004 Jan-Feb;256-257(1-2):107-15.

VDAC: the channel at the interface between mitochondria and the cytosol.

Author information

  • 1Department of Biology, University of Maryland, College Park, MD 20742, USA. mc34@umail.umd.edu

Abstract

The mitochondrial outer membrane is not just a barrier but a site of regulation of mitochondrial function. The VDAC family of proteins are the major pathways for metabolite flux through the outer membrane. These can be regulated in a variety of ways and the integration of these regulatory inputs allows mitochondrial metabolism to be adjusted to changing cellular conditions. This includes total blockage of the flux of anionic metabolites leading to permeabilization of the outer membrane to small proteins followed by apoptotic cell death.

PMID:
14977174
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk