Format

Send to:

Choose Destination
See comment in PubMed Commons below
Pharmacoepidemiol Drug Saf. 2004 Jan;13(1):1-9.

Infant vaccinations and childhood asthma among full-term infants.

Author information

  • 1Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate, Portland, OR 97227-1110, USA. john.mullooly@kpchr.org

Abstract

PURPOSE:

To determine if infant vaccinations are associated with childhood asthma among full-term infants. The secondary objective was to describe relationships between characteristics of infant wheezing and childhood asthma.

METHODS:

We used baseline data from a study of infant wheezing that selected full-term infants born into a health maintenance organization (HMO) during 1991-1994, continuously enrolled for at least 12 months and without perinatal pulmonary or other selected conditions. Information had been abstracted for infancy (0-18 months) regarding wheezing, vaccinations and asthma risk factors. Using automated data, we identified asthma cases in 1998 among those enrolled for at least 6 months during the year.

RESULTS:

A total of 1778 full-term infants met our study criterion and 9% had asthma in 1998. Childhood asthma was not significantly associated with having received Hepatitis B vaccine or age at first Hepatitis B vaccine; number of whole-cell pertussis, Haemophilis influenzae type b or oral polio vaccine doses; having received measles, mumps, rubella vaccine; or total number of vaccine doses combined. Childhood asthma was significantly associated with number of infant wheezing episodes.

CONCLUSIONS:

Our findings do not support concerns that vaccines are associated with increased risk of asthma but confirm that frequency of infant wheezing is associated with childhood asthma.

PMID:
14971117
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk