Gene therapy is one of the challenges in the medicine. The advance, which had been achieved in a molecular biology through last ten years, brought to the first clinical trials of gene therapy. This treatment method may find a big application in cardiology, for example: cardiomyopathy, restenosis and ischaemic heart disease. The main problem in the gene therapy is to supply a therapeutic gene to target cell of the patient and to express it. Clinical effectiveness of the gene therapy has not been proved yet so, therefore it is necessary to carry out more new designed researches, which would enable to accept the gene therapy as an effective treatment. Using the gene therapy beside social and ethic problems gives a lot of law's doubts.