Nutr Rev. 2003 Dec;61(12):427-31.

New paradigms for nutrient control of genome translation.

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Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

Abstract

Organisms respond adaptively to changing environmental conditions by altering genome expression. Translational control of gene expression by nutrients and metabolites is one of the most robust biologic mechanisms that enable rapid alterations in the cellular proteome in response to changes in the local environment. Recently, investigators have identified new mechanisms for nutrient control of translation in mammals; evidence supports the conservation of translational control mechanisms in eukaryotes that heretofore had only been demonstrated in prokaryotes.

PMID:: 14968913; [PubMed - indexed for MEDLINE]

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