Effectiveness and safety of ALA-IPL in treating actinic keratoses and photodamage

J Drugs Dermatol. 2004 Jan-Feb;3(1 Suppl):S36-9.

Abstract

Background: Photorejuvenation involves the use of a light source or laser in reversing the signs of aging. The Intense Pulsed Light (IPL) has demonstrated effectiveness in treating signs of photodamage. Photodynamic therapy is a relatively new and promising treatment for actinic keratoses.

Objective: To determine the effectiveness of ALA-IPL in treating actinic keratoses as well as reversing the signs of aging.

Methods: A retrospective trial of 17 patients treated with ALA-IPL. Patients were evaluated for improvement of telangiectasias, blotchy pigment, fine wrinkles, coarseness of skin and number of actinic keratoses. All side effects were recorded.

Results: 68% of actinic keratoses resolved after one treatment. There was a 55% improvement in telangiectasias, a 48% improvement in pigmentary irregularities and a 25% improvement in coarseness of skin texture. There was minimal change in fine wrinkle appearance. Side effects were minimal including mild erythema and edema for 3-5 days on average. No infections were noted.

Conclusions: ALA-IPL treatment is effective in treating both actinic keratoses and signs of photodamage. In this study, we achieved significant improvement after just one treatment. ALA-IPL is a safe, effective way to treat both actinic keratoses and photodamage with little down time.

MeSH terms

  • Adult
  • Aged
  • Aminolevulinic Acid / adverse effects
  • Aminolevulinic Acid / pharmacology*
  • Aminolevulinic Acid / therapeutic use*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Photosensitivity Disorders / drug therapy*
  • Photosensitivity Disorders / pathology
  • Phototherapy / adverse effects
  • Phototherapy / methods*
  • Retrospective Studies
  • Skin Aging / drug effects*

Substances

  • Aminolevulinic Acid