Science. 1992 Aug 7;257(5071):792-5.

Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule.

Linsley PS, Wallace PM, Johnson J, Gibson MG, Greene JL, Ledbetter JA, Singh C, Tepper MA.

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Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121.

Abstract

In vitro, when the B7 molecule on the surface of antigen-presenting cells binds to the T cell surface molecules CD28 and CTLA-4, a costimulatory signal for T cell activation is generated. CTLA4Ig is a soluble form of the extracellular domain of CTLA-4 and binds B7 with high avidity. CTLA4Ig treatment in vivo suppressed T cell-dependent antibody responses to sheep erythrocytes or keyhole limpet hemocyanin. Large doses of CTLA4Ig suppressed responses to a second immunization. Thus, costimulation by B7 is important for humoral immune responses in vivo, and interference with costimulation may be useful for treatment of antibody-mediated autoimmune disease.

PMID:: 1496399; [PubMed - indexed for MEDLINE]

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