Int Arch Allergy Immunol. 2004 Feb;133(2):198-209. Epub 2004 Feb 11.

Mosquito allergy: immune mechanisms and recombinant salivary allergens.

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Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada. zpeng@ms.umanitoba.ca

Abstract

Reactions to mosquito bites are immunological in nature, with the involvement of IgE-, IgG- and T lymphocyte-mediated hypersensitivities. Acquired desensitization to mosquito saliva may occur during childhood and adolescence or during long-term exposure to mosquito bites. Due to the lack of salivary preparations, allergic reactions to mosquito bites are underdiagnosed and undertreated. Recombinant mosquito saliva allergens with biological activity are being developed. These recombinant allergens will significantly improve diagnosis of mosquito allergy and eventually will also improve specific immunotherapy for patients with systemic reactions to mosquito bites.

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