Redox Rep. 2003;8(5):304-10.

Haemoglobinopathies and resistance to malaria.

Source

Nuffield Department of Clinical Laboratory Sciences and National Blood Service-Oxford Centre, John Radcliffe Hospital, Oxford, UK. david.roberts@ndcls.ox.ac.uk

Abstract

The haemoglobinopathies have a celebrated role in the study of human genetics as the first examples of balanced polymorphisms described in human populations. Over the last 50 years, considerable evidence has been provided to show that these traits do confer protection from malaria. More recently, the underlying mechanisms of protection have been examined. This short review summarizes these studies and where possible shows how the putative mechanisms of protection may be linked to redox processes.

PMID:: 14962371; [PubMed - indexed for MEDLINE]

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Substances

Hemoglobin, Sickle

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Malaria - MedlinePlus Health Information

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