NHMRC Clinical Centre of Research Excellence in Outcomes for Chronic Liver Disease, Centenary Research Institute, University of Sydney, Royal Prince Alfred Hospital, Australia. g.mccaughan@centenary.usyd.edu.au
Chronic hepatitis C virus infection is typically characterised by slowly progressive hepatic fibrosis. However, it is recognised that some patients do not progress while others rapidly develop significant fibrosis. Here, we review studies that have assessed factors that could influence this rate of fibrotic progression.