Hydroxymethylthiobutanoic acid spares methionine from catabolism in the chick

Ann Nutr Metab. 1992;36(5-6):245-50. doi: 10.1159/000177725.

Abstract

Two groups of chicks were fed, until they were 3 weeks old, diets supplemented with either DL-methionine (MET) or DL-2-hydroxy-4-methylthiobutanoic acid (HMB). Oxidation to CO2 and uric catabolism of intraperitoneally injected L-[1-14C]MET and DL-[1-14C]HMB were studied comparatively for 8 h. HMB supplementation spares available MET from both oxidative and uric catabolism.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbon Radioisotopes
  • Chickens / metabolism*
  • Diet*
  • Kinetics
  • Methionine / administration & dosage
  • Methionine / analogs & derivatives*
  • Methionine / metabolism*
  • Methionine / pharmacokinetics
  • Methionine / pharmacology
  • Uric Acid / metabolism

Substances

  • Carbon Radioisotopes
  • Uric Acid
  • alpha-hydroxy-gamma-methylmercaptobutyric acid
  • Methionine