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Trends Genet. 1992 Dec;8(12):446-52.

Mating-type gene switching in Saccharomyces cerevisiae.

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  • Rosenstiel Center, Brandeis University, Waltham, MA 02254.


The study of yeast mating-type (MAT) gene switching has provided insights into several aspects of the regulation of gene expression. MAT switching is accomplished by a highly programmed site-specific homologous recombination event in which mating-type-specific sequences at MAT are replaced by alternative DNA sequences copied from one of two unexpressed donors. The mating-type system has also provided an opportunity to study both the genetic regulation of gene silencing by alterations in chromatin structure, and the basis of preferential recombination between a recipient of genetic information and one of several possible donors.

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