Eur Neuropsychopharmacol. 1992 Dec;2(4):421-4.

Beta-endorphin responses to metyrapone and dexamethasone in depressed patients.

Morphy MA, Fava GA, Pedersen RC, Zielezny M, Sonino N, Brownie AC.

Source

Department of Psychiatry, State University of New York, Buffalo.

Abstract

Controversy continues over the characteristics of beta-endorphin secretion in depression. Beta-endorphin plasma levels were measured in 30 drug-free male patients with a DSM-III-R major depressive disorder and 21 healthy controls. Depressed patients displayed significantly lower beta-endorphin plasma levels in baseline conditions, after the single dose metyrapone test, and after the dexamethasone suppression test. The activation of hypothalamic-pituitary-adrenal (HPA) axis in depression might be due, at least in part, to low levels of beta-endorphin. These results suggest that HPA axis dysregulation in depression may involve peptides other than ACTH.

PMID:: 1490094; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Effects of metyrapone and dexamethasone on pro-gamma-MSH and ACTH levels in depressed patients. [Eur Neuropsychopharmacol. 1990]
Effects of metyrapone and dexamethasone on pro-gamma-MSH and ACTH levels in depressed patients.
Sonino N, Fava GA, Morphy MA, Pedersen RC. Eur Neuropsychopharmacol. 1990 Nov; 1(1):63-5.
Effects of metyrapone and dexamethasone upon pro-gamma-MSH plasma levels in depressed patients and healthy controls. [J Affect Disord. 1990]
Effects of metyrapone and dexamethasone upon pro-gamma-MSH plasma levels in depressed patients and healthy controls.
Morphy MA, Fava GA, Pedersen RC, Zielezny M, Sonino N, Brownie AC. J Affect Disord. 1990 Jul; 19(3):183-9.
Dysregulation of plasma pro-opiomelanocortin-related peptides in neurotic depression. [Acta Endocrinol (Copenh). 1986]
Dysregulation of plasma pro-opiomelanocortin-related peptides in neurotic depression.
Genazzani AR, Petraglia F, Sinforiani E, Brambilla F, Facchinetti F, Nappi G. Acta Endocrinol (Copenh). 1986 May; 112(1):1-6.
Review Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior. [ScientificWorldJournal. 2006]
Review Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior.
Sher L. ScientificWorldJournal. 2006 Oct 31; 6:1398-404. Epub 2006 Oct 31.
Review Neuroendocrinological mechanisms of actions of antidepressant drugs. [J Neuroendocrinol. 2007]
Review Neuroendocrinological mechanisms of actions of antidepressant drugs.
Schüle C. J Neuroendocrinol. 2007 Mar; 19(3):213-26.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Beta-endorphin responses to metyrapone and dexamethasone in depressed patients.
Beta-endorphin responses to metyrapone and dexamethasone in depressed patients.
Eur Neuropsychopharmacol. 1992 Dec ;2(4):421-4.

PubMed
The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, ...
The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement.
J Spinal Disord. 1992 Dec ;5(4):383-9; discussion 397.

PubMed
Some electrophysiological observations on isolated single myelinated nerve fibre...
Some electrophysiological observations on isolated single myelinated nerve fibres (saltatory conduction).
J Physiol. 1951 Oct 29 ;115(2):177-84.

PubMed
Concentrations of purine nucleotides and purine and pyrimidine bases in cerebros...
Concentrations of purine nucleotides and purine and pyrimidine bases in cerebrospinal fluid of neurologically healthy children.
Eur J Clin Chem Clin Biochem. 1992 Nov ;30(11):761-5.

PubMed
Erythrokeratodermia variabilis in a Jewish Kurdish family.
Erythrokeratodermia variabilis in a Jewish Kurdish family.
Clin Genet. 1978 May ;13(5):404-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Beta-endorphin responses to metyrapone and dexamethasone in depressed patients.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information