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Gene. 1992 Dec 15;122(2):387-8.

Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1.

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  • 1Department of Pediatrics, Kumamoto University School of Medicine, Japan.


Pit-1 is a pituitary-specific transcription factor that binds to and transactivates promoters of growth hormone- and prolactin-encoding genes. A chromosomal gene related to human Pit-1 isolated from human gene libraries was over 14 kb long and split into six exons. All of the splice donor and acceptor sites conformed to the GT/AG rule. The gene was mapped to human chromosome region 3p11.

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