Cytogenet Cell Genet. 1992;61(4):271-3.

The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization.

Rao VV, Löffler C, Battey J, Hansmann I.

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Institut für Humangenetik, Universität Göttingen, Germany.

Abstract

Two posterior pituitary hormones oxytocin and arginine-vasopressin control the important activities of water excretion, parturition and lactation. Both these hormones are synthesized as inactive precursors in the hypothalamus along with their carrier proteins neurophysin I and neurophysin II respectively and are activated upon transport to posterior pituitary. Human genes for both oxytocin-neurophysin I (OXT) and arginine-vasopressin-neurophysin II (ARVP) are cloned and found to be linked on chromosome 20 separated by approximately 12 kb of intergenic sequences. Though OXT is not yet associated with any disease, ARVP is linked to the autosomal dominant disease neurohypophyseal diabetes insipidus (AD-NDI). We have mapped regionally the OXT locus to chromosome 20p13 by both radioactive (ISH) and fluorescence in situ hybridization (FISH).

PMID:: 1486803; [PubMed - indexed for MEDLINE]

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The pituitary hormones arginine vasopressin-neurophysin II and oxytocin-neurophysin I show close linkage with interleukin-1 on mouse chromosome 2. [Genomics. 1993]
The pituitary hormones arginine vasopressin-neurophysin II and oxytocin-neurophysin I show close linkage with interleukin-1 on mouse chromosome 2.
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Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on chromosome 20. [Mol Endocrinol. 1990]
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A novel mutation (R97C) in the neurophysin moiety of prepro-vasopressin-neurophysin II associated with autosomal-dominant neurohypophyseal diabetes insipidus. [Mol Genet Metab. 1999]
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Rutishauser J, Kopp P, Gaskill MB, Kotlar TJ, Robertson GL. Mol Genet Metab. 1999 May; 67(1):89-92.
Review Molecular biology of diabetes insipidus. [Annu Rev Med. 1995]
Review Molecular biology of diabetes insipidus.
Fujiwara TM, Morgan K, Bichet DG. Annu Rev Med. 1995; 46:331-43.
Review Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors. [Biochimie. 1988]
Review Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors.
Acher R, Chauvet J. Biochimie. 1988 Sep; 70(9):1197-207.

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Cited by 1 PubMed Central article

Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms. [BMC Gastroenterol. 2009]
Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms.
Truedsson M, Carlson J, Simrén M, Ohlsson B. BMC Gastroenterol. 2009 Nov 30; 9:90. Epub 2009 Nov 30.

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