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    J Infect Dis. 2004 Feb 15;189(4):583-6. Epub 2004 Jan 29.

    MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment.

    Bleiber G, May M, Suarez C, Martinez R, Marzolini C, Egger M, Telenti A; Swiss HIV Cohort Study.

    Institute of Microbiology and Division of Infectious Diseases, University Hospital of Lausanne, Lausanne, Switzerland.

    Nonphysiological overexpression of the ABC transporter P-glycoprotein (P-gp), which is encoded by MDR1, has been associated with reduced susceptibility to human immunodeficiency virus (HIV) type 1 infection in vitro. We analyzed (1) the expression and genotype of MDR1 and their relationship to HIV-1 permissiveness of CD4+ T cells from 128 healthy blood donors and (2) the role that alleles of MDR1 exons 21 and 26 play in modifying disease progression in 411 HIV-1-infected individuals. Differences in physiological levels of MDR1 expression did not modify HIV-1 infection in vitro, nor did MDR1 alleles and haplotypes significantly influence either permissiveness to infection in vitro or disease progression in vivo before the initiation of treatment.

    PMID: 14767809 [PubMed - indexed for MEDLINE]

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