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    Neuron. 2004 Feb 5;41(3):311-3.

    Vesicle priming and depriming: a SNAP decision.

    Heidelberger R, Matthews G.

    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 77030 USA, USA.

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    Synapses have a limited pool of vesicles that are docked and primed for rapid release. In neuroendocrine cells, splice variants of the SNARE protein SNAP-25 and phosphorylation of SNAP-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate of vesicle depriming. Pre- and posttranslational modifications of SNAP-25 may therefore affect synaptic strength.

    PMID: 14766170 [PubMed - indexed for MEDLINE]

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