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    Nature. 2004 Feb 5;427(6974):504.

    Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids.

    Kang JX, Wang J, Wu L, Kang ZB.

    Source

    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. kang.jing@mgh.harvard.edu

    Erratum in

    • Nature. 2004 Feb 19;427(6976):698.

    Abstract

    Mammals cannot naturally produce omega-3 (n-3) fatty acids--beneficial nutrients found mainly in fish oil--from the more abundant omega-6 (n-6) fatty acids and so they must rely on a dietary supply. Here we show that mice engineered to carry a fat-1 gene from the roundworm Caenorhabditis elegans can add a double bond into an unsaturated fatty-acid hydrocarbon chain and convert n-6 to n-3 fatty acids. This results in an abundance of n-3 and a reduction in n-6 fatty acids in the organs and tissues of these mice, in the absence of dietary n-3. As well as presenting an opportunity to investigate the roles played by n-3 fatty acids in the body, our discovery indicates that this technology might be adapted to enrich n-3 fatty acids in animal products such as meat, milk and eggs.

    PMID:
    14765186
    [PubMed - indexed for MEDLINE]

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