Rewiring the transcriptional regulatory circuits of cells.

Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin 2, Ireland.

The molecular mechanisms that regulate gene expression can evolve either by changing the cis-acting DNA elements in promoters, or by replacing the trans-acting regulatory proteins. New data from yeast species show that both processes can happen.

PMID: 14759249 [PubMed - indexed for MEDLINE]

PMCID: PMC395740