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J Clin Invest. 2004 Feb;113(3):340-5.

Central role of the P2Y12 receptor in platelet activation.

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  • 1Department of Pharmacology, Temple University Medical School, Philadelphia, Pennsylvania 19140, USA.


Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value.

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