Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Psychiatry. 2004 Feb;161(2):370-2.

Response to tricyclic antidepressants: independent of gender?

Author information

  • 1Medicines Evaluation Board of the Netherlands, Den Haag, The Netherlands. t.wohlfarth@CBG-MEB.nl

Abstract

OBJECTIVE:

The authors examined gender differences in response to tricyclic antidepressants.

METHOD:

A total of 30 randomized, placebo-controlled trials that included 3,886 patients (1,555 men and 2,331 women), submitted between 1979 and 1991 in order to obtain marketing authorization, were reviewed. Gender differences in response to treatment were tested in various multiple regression models using a variety of response definitions.

RESULTS:

Different response definitions all pointed to no gender difference in the efficacy of tricyclic antidepressants. The estimated effect size was similar for women younger and older than age 50 and for men.

CONCLUSIONS:

Tricyclic antidepressant response is independent of gender.

PMID:
14754791
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk