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Cell Cycle. 2004 Apr;3(4):396-400. Epub 2004 Apr 1.

Polycomb group proteins in cell cycle progression and cancer.

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  • 1Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.


Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.

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