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Stroke. 2004 Mar;35(3):633-7. Epub 2004 Jan 29.

Active and passive smoking and the risk of subarachnoid hemorrhage: an international population-based case-control study.

Author information

  • 1Clinical Trials Research Unit, University of Auckland, Private Bag 92019, Auckland, New Zealand. c.anderson@ctru.auckland.ac.nz

Abstract

BACKGROUND AND PURPOSE:

This study was undertaken to better clarify the risks associated with cigarette smoking and subarachnoid hemorrhage (SAH).

METHODS:

The study included 432 incident cases of SAH frequency matched to 473 community SAH-free controls to determine dose-dependent associations of active and passive smoking (at home) and smoking cessation with SAH.

RESULTS:

Compared with never smokers not exposed to passive smoking, the adjusted odds ratio for SAH among current smokers was 5.0 (95% confidence interval [CI], 3.1 to 8.1); for past smokers, 1.2 (95% CI, 0.8 to 2.0); and for passive smokers, 0.9 (95% CI, 0.6 to 1.5). Current and lifetime exposures showed a clear dose-dependent effect, and risks appeared more prominent in women and for aneurysmal SAH. Approximately 1 in 3 cases of SAH could be attributed to current smoking, but risks decline quickly after smoking cessation, even among heavy smokers.

CONCLUSIONS:

A strong positive association was found between cigarette smoking and SAH, especially for aneurysmal SAH and women, which is virtually eliminated within a few years of smoking cessation. Large opportunities exist for preventing SAH through smoking avoidance and cessation programs.

PMID:
14752125
[PubMed - indexed for MEDLINE]
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