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J Neuroimaging. 2004 Jan;14(1):54-7.

Multiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone state.

Author information

  • 1National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Room B1D733, MSC 1063, Bethesda, MD 20892-1063, USA. chalelaj@ninds.nih.gov

Abstract

BACKGROUND:

Recent reports have indicated that cerebral microbleeds (CMBs) detected on gradient-echo (GRF) magnetic resonance imaging may be a risk factor for therapy related intracranial hemorrhages (ICHs).

CASE DESCRIPTION:

The authors describe 3 patients with multiple CMBs in whom ICHs occurred either after tissue plasminogen activator administration or after the initiation of antiplatelet therapy. Hemorrhages occurred in brain areas with normal appearances on GRE imaging and remote from the CMBs.

CONCLUSION:

Multiple CMBs may signal a diffuse hemorrhage-prone vasculopathy.

PMID:
14748209
[PubMed - indexed for MEDLINE]
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