Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cell Biol. 2004 Feb 2;164(3):417-26. Epub 2004 Jan 26.

WASp is required for the correct temporal morphogenesis of rhabdomere microvilli.

Author information

  • 1Division of Biology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0649, USA. azelhof@biomail.ucsd.edu

Abstract

Microvilli are actin-based fingerlike membrane projections that form the basis of the brush border of enterocytes and the Drosophila melanogaster photoreceptor rhabdomere. Although many microvillar cytoskeletal components have been identified, the molecular basis of microvillus formation is largely undefined. Here, we report that the Wiskott-Aldrich syndrome protein (WASp) is necessary for rhabdomere microvillus morphogenesis. We show that WASp accumulates on the photoreceptor apical surface before microvillus formation, and at the time of microvillus initiation WASp colocalizes with amphiphysin and moesin. The loss of WASp delays the enrichment of F-actin on the apical photoreceptor surface, delays the appearance of the primordial microvillar projections, and subsequently leads to malformed rhabdomeres.

Copyright The Rockefeller University Press

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk