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Cell. 2004 Jan 23;116(2):281-97.

MicroRNAs: genomics, biogenesis, mechanism, and function.

Author information

  • Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. dbartel@wi.mit.edu

Abstract

MicroRNAs (miRNAs) are endogenous approximately 22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.

PMID:
14744438
[PubMed - indexed for MEDLINE]
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