Cell. 2004 Jan 23;116(2):191-203.

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems.

Source

Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada. pawson@mshri.on.ca

Abstract

Over the last two decades, a new and unifying concept of cellular organization has emerged in which modular protein-protein interactions provide an underlying framework through which signaling pathways are assembled and controlled. In this scheme, posttranslational modifications such as phosphorylation commonly exert their biological effects by regulating molecular interactions, exemplified by the ability of phosphotyrosine sites to bind selectively to SH2 domains. Although these interactions are rather simple in isolation, they can nonetheless be exploited to generate complex cellular systems. Here, I discuss experiments that have led to this view of dynamic cellular behavior and identify some current and future areas of interest in cell signaling.

PMID:: 14744431; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. [Mol Cell. 2006]
The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling.
Liu BA, Jablonowski K, Raina M, Arcé M, Pawson T, Nash PD. Mol Cell. 2006 Jun 23; 22(6):851-68.
High-throughput phosphotyrosine profiling using SH2 domains. [Mol Cell. 2007]
High-throughput phosphotyrosine profiling using SH2 domains.
Machida K, Thompson CM, Dierck K, Jablonowski K, Kärkkäinen S, Liu B, Zhang H, Nash PD, Newman DK, Nollau P, et al. Mol Cell. 2007 Jun 22; 26(6):899-915.
Review From Src Homology domains to other signaling modules: proposal of the 'protein recognition code'. [Oncogene. 1998]
Review From Src Homology domains to other signaling modules: proposal of the 'protein recognition code'.
Sudol M. Oncogene. 1998 Sep 17; 17(11 Reviews):1469-74.
A novel mechanism-based mammalian cell assay for the identification of SH2-domain-specific protein-protein inhibitors. [Chem Biol. 1998]
A novel mechanism-based mammalian cell assay for the identification of SH2-domain-specific protein-protein inhibitors.
Rickles RJ, Henry PA, Guan W, Azimioara M, Shakespeare WC, Violette S, Zoller MJ. Chem Biol. 1998 Oct; 5(10):529-38.
Review Molecular recognition by SH2 domains. [Adv Protein Chem. 2002]
Review Molecular recognition by SH2 domains.
Bradshaw JM, Waksman G. Adv Protein Chem. 2002; 61:161-210.

See reviews... See all...

Cited by over 100 PubMed Central articles

On the Control of TCR Phosphorylation. [Front Immunol. 2012]
On the Control of TCR Phosphorylation.
Fernandes RA, Huo J, Lui Y, Felce JH, Davis SJ. Front Immunol. 2012; 3:92. Epub 2012 May 7.
SPPS: a sequence-based method for predicting probability of protein-protein interaction partners. [PLoS One. 2012]
SPPS: a sequence-based method for predicting probability of protein-protein interaction partners.
Liu X, Liu B, Huang Z, Shi T, Chen Y, Zhang J. PLoS One. 2012; 7(1):e30938. Epub 2012 Jan 26.
Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. [J Exp Med. 2011]
Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.
Xu D, Liu X, Yu WM, Meyerson HJ, Guo C, Gerson SL, Qu CK. J Exp Med. 2011 Sep 26; 208(10):1977-88. Epub 2011 Sep 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions...
Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems.
Cell. 2004 Jan 23 ;116(2):191-203.

PubMed
Stinging nettle dermatitis.
Stinging nettle dermatitis.
Am J Contact Dermat. 2003 Mar ;14(1):44-6.

PubMed
Mechanisms of host defence against fungal infection.
Mechanisms of host defence against fungal infection.
J Med Vet Mycol. 1992 ;30 Suppl 1:167-77.

PubMed
[The correlation between Kawasaki disease and polymorphisms of Tumor necrosis fa...
[The correlation between Kawasaki disease and polymorphisms of Tumor necrosis factor alpha and interleukin-10 gene promoter].
Zhonghua Er Ke Za Zhi. 2003 Aug ;41(8):598-602.

PubMed
Carotid angioplasty and stenting versus carotid endarterectomy for treatment of ...
Carotid angioplasty and stenting versus carotid endarterectomy for treatment of asymptomatic carotid stenosis: a randomized trial in a community hospital.
Neurosurgery. 2004 Feb ;54(2):318-24; discussion 324-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: