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Antimicrob Agents Chemother. 2004 Feb;48(2):619-22.

Ribosomal alterations contribute to bacterial resistance against the dipeptide antibiotic TAN 1057.

Author information

  • 1Department of Antiinfectives, Pharma Research, Bayer Health Care AG, D-42096 Wuppertal, Germany.

Abstract

TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations in the ribosomes contribute to the resistance of the bacteria.

PMID:
14742220
[PubMed - indexed for MEDLINE]
PMCID:
PMC321526
Free PMC Article
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